Can we lose Salvation?

I don't know the answer to it, but I believe that if you misuse, disrespect, and act presumptuously with the anointing God has poured out on you in his mercy and kindness, you stand to loose it and pay a steep price for it. My caution would be that we need to continuously pray for God's Saving Grace to keep us on course in a manner that would be pleasing to Him.  This is what the Bible says...

Apostle Paul writes in Romans 11:17-23 (NLT),

But some of these branches from Abraham's tree, some of the Jews, have been broken off.  And you Gentiles, who were branches from a wild olive tree, were grafted in.  So now you also receive the blessing God has promised Abraham and his children, sharing in God's rich nourishment of his special olive tree.  But you must be careful not to brag about being grafted in to replace the branches that were broken off.  Remember, you are just a branch, not the root.  "Well," you may say, "those branches were broken off to make room for me." yes, but remember-those branches, the Jews, were broken off because they didn't believe God, and you are there because you do believe.  Don't think highly of yourself, but fear what could happen.  For if God did not spare the branches he put therein the first place, he won't spare you either.  Notice how God is both kind and severe.  He is severe to those who disobeyed, but kind to you as you continue to trust in his kindness. But if you stop trusting, you also will be cut off. And if the Jews turn from their unbelief, God will graft them back into the tree again.  He has the power to do it.

Ezekiel 18:24, says,

"However, if righteous people turn to sinful ways and start acting like other sinners, should they be allowed to live? No, of course not! All their previous goodness will be forgotten, and they will die for their sins."

Such a seemingly harsh stance of God was softened on Calvary's cross, where Jesus Christ the only begotten son of God, took upon himself the wrath of God towards man's sins. Isaiah prophesied of this Saving Grace, when he said in Isaiah 53,

"...Yet it was our weaknesses he carried; it was our sorrows that weighted him down.  And we thought his troubles were a punishment from God for his own sins! But he was wounded  and crushed for our sins.  He was beaten that we might have peace.  He was whipped, and we were healed! All of us have strayed away like sheep.  We have left God's paths to follow our own.  Yet the LORD laid on him the guilt and sins of us all...

But who among the people realized that he was dying for their sins - that he was suffering their punishment? He had done no wrong, and he never deceived anyone...

But it was the LORD'S good plan to crush him and fill him with grief.  Yet when his life is made an offering for sin, he will have a multitude of children, many heirs...

And because of what he has experienced, my righteous servant will make it possible for many to be counted righteous, for he will bear all their sins...

He bore the sins of many and interceded for sinners."

In Mathew 27:45, we read that Jesus bore it all for us on his own, as he cried out before giving up his ghost, "Eli, Eli, lema sabachthani?" which means, "My God, my God, why have you forsaken me?" Father God laid it all, the burden of the entire mankind's sin and the punishment for it on his son.

Even so, we should take to heart the lessons from the Bible regarding folks who were anointed by God, but lost that anointing because of their sinful ways; people who started off well,  but the end was less than glorious or was full of turmoil and pain.  There was Saul, anointed king over Israel, but because of his selfish pride ended his life in failure, taking his life by his own sword; there was Solomon, whom God called Jedidiah - God's beloved.  He was the wisest among all men, the richest king in the whole wide world, whose reign was one of the most peaceful in Israel's history, but his sinful ways resulted in God taking away 9/10ths of his kingdom and giving it to one of his servants during his son's reign (God kept his word to keep the kingdom together during Solomon's reign!).  There was the anointed Sampson, the mighty warrior, whose sinful ways led to his capture and humiliation at the hands of his enemies.  There also was David, Solomon's father, whom God called a man after God's own heart, whose sins though God forgave, as a truly repentant David would fall at God's feet for mercy, was punished by continual strife in his family all through his lifetime.  God loved him, yet he punished him for his sins!

Paul warns us about deliberate/presumptuous sins in Galatians 6:7-8, "Don't be misled.  Remember that you can't ignore God and get away with it.  You will always reap  what you sow!  Those who live only to satisfy their own sinful desires will harvest the consequences of decay and death.  But those who live to please the Spirit will harvest everlasting life from the Spirit." He further writes in Hebrews 6:4-6, "For it is impossible* to restore those who were once enlightened -- those who have experienced the good things of heaven and shared in the Holy Spirit, who have tasted the goodness of the word of God and the power of the age to come --and who then turn away from God.  It is impossible to bring such people to repentance again because they are nailing the Son of God to the cross again by rejecting him, holding him up to public shame.

Let us not deceive ourselves, but pray as in David's Psalms 19:12-13, "How can I know all the sins lurking in my heart? Cleanse me from these hidden faults.  Keep me from deliberate sins! [presumptuous sins - knowingly committed expecting God's forgiveness] don't let them control me.  Then I will be free of guilt and innocent of great sin."

God understands our shortcomings and in Mathew 6:9-13, the Lord Jesus teaches us how to pray to the Father in Heaven - the Lord's Prayer. I want to emphasize vs. 13, where the Lord teaches us, "And don't let us yield to temptation, but deliver us from evil. For yours is the kingdom and the power and the glory forever. Amen." Ask God for his grace, for he is the LORD of all, to strengthen us in our weakest moments, help us not to fall. In 1 Corinthians 10:13, Paul writes, "But remember that the temptations that come into your life are no different from what others experience.  And God is faithful.  He will keep the temptation from becoming so strong that you can't stand up against it.  When you are tempted, he will show you a way out so that you will not give in to it."

In conclusion, let our prayers be as David's in Psalms 139:23-24, "Search me, O God, and know my heart; test me and know my thoughts.  Point out anything in me that offends you, and lead me along the path of everlasting life."  May God bless you and keep you strong until the very end!

* I want to post here a message from J. Vernon McGee on Hebrews 6:4-6